Rome, the Eternal City, offers a wealth of historical, cultural, and culinary experiences for first-time visitors. To ensure a smooth and enjoyable trip, plan your itinerary around must-see sites like the Colosseum, Roman Forum, Pantheon, and Vatican City. Book admission tickets in advance and consider your accommodation in neighborhoods like Trastevere, Centro Storico, Monti, or Vatican City area. Familiarize yourself with public transportation options, and pack accordingly for the season of your visit. Lastly, understand local customs, dining etiquette, and safety tips to make the most of your Roman experience.